Category: Science


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Now they’re just messing with us. Physicists have long known that quantum mechanics allows for a subtle connection between quantum particles called entanglement, in which measuring one particle can instantly set the otherwise uncertain condition, or “state,” of another particle—even if it’s light years away. Now, experimenters in Israel have shown that they can entangle two photons that don’t even exist at the same time.

“It’s really cool,” says Jeremy O’Brien, an experimenter at the University of Bristol in the United Kingdom, who was not involved in the work. Such time-separated entanglement is predicted by standard quantum theory, O’Brien says, “but it’s certainly not widely appreciated, and I don’t know if it’s been clearly articulated before.”

Entanglement is a kind of order that lurks within the uncertainty of quantum theory. Suppose you have a quantum particle of light, or photon. It can be polarized so that it wriggles either vertically or horizontally. The quantum realm is also hazed over with unavoidable uncertainty, and thanks to such quantum uncertainty, a photon can also be polarized vertically and horizontally at the same time. If you then measure the photon, however, you will find it either horizontally polarized or vertically polarized, as the two-ways-at-once state randomly “collapses” one way or the other.

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Scientists from the University of Southampton have developed a device which records the brain activity of worms to help test the effects of drugs.

NeuroChip is a microfluidic electrophysiological device, which can trap the microscopic worm Caenorhadbitis elegans and record the activity of discrete neural circuits in its ‘brain’ – a worm equivalent of the EEG.

C. elegans have been enormously important in providing insight into fundamental signalling processes in the nervous system and this device opens the way for a new analysis. Prior to this development, electrophysiological recordings that resolve the activity of excitatory and inhibitory nerve cells in the nervous system of the worm required a high level of technical expertise – single microscopic (1mm long) worms have to be trapped on the end of a glass tube, a microelectrode, in order to make the recording. The worms are very mobile as well as being small and this can be a challenging procedure.

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The Quantum Artificial Intelligence Lab will use the most advanced commercially available quantum computer, the D-Wave Two.

D-Wave computer chip

Quantum computing took a giant leap forward on the world stage today as NASA and Google, in partnership with a consortium of universities, launched an initiative to investigate how the technology might lead to breakthroughs in artificial intelligence.

The new Quantum Artificial Intelligence Lab will employ what may be the most advanced commercially available quantum computer, the D-Wave Two, which a recent study confirmed was much faster than conventional machines at defeating specific problems . The machine will be installed at the NASA Advanced Supercomputing Facility at the Ames Research Center in Silicon Valley and is expected to be available for government, industrial, and university research later this year.

Google believes quantum computing might help it improve its Web search and speech recognition technology. University researchers might use it to devise better models of disease and climate, among many other possibilities. As for NASA, “computers play a much bigger role within NASA missions than most people realize,” says quantum computing expert Colin Williams, director of business development and strategic partnerships at D-Wave. “Examples today include using supercomputers to model space weather, simulate planetary atmospheres, explore magnetohydrodynamics, mimic galactic collisions, simulate hypersonic vehicles, and analyze large amounts of mission data.”

Quantum computers exploit the bizarre quantum-mechanical properties of atoms and other building blocks of the cosmos. At itse very smallest scale, the universe becomes a fuzzy, surreal place—objects can seemingly exist in more than one place at once or spin in opposite directions at the same time.

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Researchers have pinpointed a catalytic trigger for the onset of Alzheimer’s disease – when the fundamental structure of a protein molecule changes to cause a chain reaction that leads to the death of neurons in the brain.

For the first time, scientists at Cambridge’s Department of Chemistry have been able to map in detail the pathway that generates “aberrant” forms of proteins which are at the root of neurodegenerative conditions such as Alzheimer’s.

They believe the breakthrough is a vital step closer to increased capabilities for earlier diagnosis of neurological disorders such as Alzheimer’s and Parkinson’s, and opens up possibilities for a new generation of targeted drugs, as scientists say they have uncovered the earliest stages of the development of Alzheimer’s that drugs could possibly target.

The study, published today in the journal PNAS, is a milestone in the long-term research established in Cambridge by Professor Christopher Dobson and his colleagues, following the realisation by Dobson of the underlying nature of protein ‘misfolding’ and its connection with disease over 15 years ago.

The research is likely to have a central role to play in diagnostic and drug development for dementia-related diseases, which are increasingly prevalent and damaging as populations live longer.

“There are no disease modifying therapies for Alzheimer’s and dementia at the moment, only limited treatment for symptoms. We have to solve what happens at the molecular level before we can progress and have real impact,” said Dr Tuomas Knowles, lead author of the study and long-time collaborator of Professor Dobson.

“We’ve now established the pathway that shows how the toxic species that cause cell death, the oligomers, are formed. This is the key pathway to detect, target and intervene – the molecular catalyst that underlies the pathology.”

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Scientists in the US have developed a calculator from living cells, using old-fashioned analog programming. Their hope is that the technology could be used in the future to program cells to kill cancer.

Researchers have previously built electronic circuits using living cells. They achieved this by forcing living cells to behave in binary (digital) systems. But this is not energy efficient. And many cells are required to implement simple functions that transistors, the basic units of electronic circuits which are ten times smaller than a cell and more reliable, can perform.

Instead analog technology, which uses not just two states like digital but many, could be used to make cells do more complex tasks. Rahul Sarpeshkar, of the Massachusetts Institute of Technology, realised that chemical reactions inside a living cell are also analog in nature.

Chris Myers at the University of Utah, who like Sarpeshkar is an electrical engineer working on biological systems agrees. “Natural systems are more analog than digital,” he said. “They are also a million times more power efficient than our electrical systems despite using very poor components that produce lots of noise.”

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Cloned human embryonic stem cell (Credit: OHSU/Flickr)

An international team of scientists announced today that for the first time ever, they were able to create new human stem cells by cloning older, fully mature human cells. The process cannot be used to create full human clones, as the scientists involved were quick to point out, but it does allow for cells to be grown to fit specific functions within an individual’s body — resulting in new, patient-specific liver cells or heart cells that actually pulse on their own, for example.

Eventually, scientists hope to refine the process to the point it could be used to help treat disease and even create whole custom organs, but that is likely to be several years away at the earliest. “While there is much work to be done in developing safe and effective stem cell treatments, we believe this is a significant step forward in developing the cells that could be used in regenerative medicine,” said Shoukhrat Mitalipov, the leader of the research team and a senior scientist at the Oregon National Primate Research Center (ONPRC), in a news release.

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D-Wave Systems Inc., the world’s first commercial quantum computing company, today announced that its new 512-qubit quantum computer, the D-Wave Two, will be installed at the new Quantum Artificial Intelligence Lab, a collaboration among NASA, Google and the Universities Space Research Association (USRA). The purpose of this effort is to use quantum computing to advance machine learning in order to solve some of the most challenging computer science problems. Installation has already begun at NASA’s Ames Research Center in Moffett Field, California, and the system is expected to be available to researchers during Q3.

Researchers at Google, NASA and USRA expect to use the D-Wave system to develop applications for a broad range of complex problems such as machine learning, web search, speech recognition, planning and scheduling, search for exoplanets, and support operations in mission control centers. Via USRA, the system will also be available to the broader U.S. academic community.

“D-Wave has made significant strides in the technology, application and now commercialization of quantum computing,” said said Steve Conway, IDC research vice president for high performance computing. “The order for a D-Wave Two system for the initiative launched by NASA, Google and USRA attests to the revolutionary potential of this fundamentally different approach to computing for both industry and government. HPC buyers and users are looking for ways to speed up their applications beyond what contemporary technologies can deliver. IDC believes organizations that depend on leading-edge technology would do well to begin exploring the possibilities for quantum computing.”

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The ability of cells to move and change shape is significant in many biological processes. White blood corpuscles gather at “hotspots” like infections and inflammations. Stem cells in the embryo move off in different directions to make the organs of the body. One unwanted movement is the movement of tumour cells, which lead to cancer metastasis.

Cells have a clear leading and trailing edge and move by a broad, thin membrane protrusion shooting out in front while the rest of the cell follows it. Small, finger-like filopodia (the green parts of the human renal cell pictured at left) can also project out from the protrusion, probably a type of cellular antenna that senses the chemical environment – bacterial secretions, for example.

But what governs this ability to move? Water, say the Linköping research team, who set out their hypothesis in the scientific journal PLOS One.

For a cell to be able to initiate a movement there needs to be a complex interaction between the outer cell membrane and the cytoskeleton on the inside. One of the most important components is the protein actin, which has the ability to create dynamic fibres that can grow at one end and recede at the other. The current thinking is that, in this way, the membrane can push out and create the protrusions. But experiments and modelling have led the LiU researchers to another picture of the mechanism.

“We looked at how cells create the membrane protrusions they need in order to be able to move. We showed that the water flow out of and into the cells through water channels, or aquaporins, in the cell membrane is important,” says Thommie Karlsson, researcher in medical microbiology and principal author of the article.

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A group at Tokyo Institute of Technology, led by Dr. Osamu Hasegawa, has succeeded in making further advances with SOINN, their machine learning algorithm, which can now use the internet to learn how to perform new tasks. The system, which is under development as an artificial brain for autonomous mental development robots, is currently being used to learn about objects in photos using image searches on the internet. It can also take aspects of other known objects and combine them to make guesses about objects it doesn’t yet recognize.

A group of students from the Royal College of Art in London has developed headsets that allow the wearer to adjust their sight and hearing in the same way they’d control the settings on a TV or radio (+ movie).

The Eidos equipment was developed to enhance sensory perception by tuning in to specific sounds or images amongst a barrage of sonic and visual information, then applying effects to enhance the important ones.

“We’ve found that while we experience the world as many overlapping signals, we can use technology to first isolate and then amplify the one we want,” say the designers.

Eidos by Tim Bouckley, Millie Clive-Smith, Mi Eun Kim and Yuta Sugawara

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In the very early hours of the morning, in a Harvard robotics laboratory last summer, an insect took flight. Half the size of a paperclip, weighing less than a tenth of a gram, it leapt a few inches, hovered for a moment on fragile, flapping wings, and then sped along a preset route through the air.

Like a proud parent watching a child take its first steps, graduate student Pakpong Chirarattananon immediately captured a video of the fledgling and emailed it to his adviser and colleagues at 3 a.m. — subject line, “Flight of the RoboBee.”

“I was so excited, I couldn’t sleep,” recalls Chirarattananon, co-lead author of a paper published this week in Science.

The demonstration of the first controlled flight of an insect-sized robot is the culmination of more than a decade’s work, led by researchers at the Harvard School of Engineering and Applied Sciences (SEAS) and the Wyss Institute for Biologically Inspired Engineering at Harvard.

“This is what I have been trying to do for literally the last 12 years,” says Robert J. Wood, Charles River Professor of Engineering and Applied Sciences at SEAS, Wyss Core Faculty Member, and principal investigator of the National Science Foundation-supported RoboBee project. “It’s really only because of this lab’s recent breakthroughs in manufacturing, materials, and design that we have even been able to try this. And it just worked, spectacularly well.”

Inspired by the biology of a fly, with submillimeter-scale anatomy and two wafer-thin wings that flap almost invisibly, 120 times per second, the tiny device not only represents the absolute cutting edge of micromanufacturing and control systems; it is an aspiration that has impelled innovation in these fields by dozens of researchers across Harvard for years.

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You’re about to see the movie that holds the Guinness World Records record for the World’s Smallest Stop-Motion Film. The ability to move single atoms — the smallest particles of any element in the universe — is crucial to IBM’s research in the field of atomic memory. But even nanophysicists need to have a little fun. In that spirit, IBM researchers used a scanning tunneling microscope to move thousands of carbon monoxide molecules (two atoms stacked on top of each other), all in pursuit of making a movie so small it can be seen only when you magnify it 100 million times. A movie made with atoms. Learn more about atomic memory, data storage and big data at http://www.ibm.com/madewithatoms

Camera system

A digital camera that functions like an insect’s compound eye is reported in the journal Nature this week.

It comprises an array of 180 small lenses, which, along with their associated electronics, are stretched across a curved mounting.

The prototype currently has few pixels, so its images are low-resolution.

But the device displays an immense depth of field, and a very wide-angle view that avoids the distortion seen in standard camera lenses.

The development team, led from the University of Illinois at Urbana-Champaign, US, believes its new imaging system could eventually find uses in surveillance and for endoscopic investigations of the human body.

In their report, the researchers also suggest such cameras could be fitted to tiny aerial vehicles one day that behaved like robotic insects.

At the moment, the “bug-eye” system’s vision is comparable to that enjoyed by some ants and beetles.

The expectation, however, is that the array can be greatly enlarged.

“The compound design of the fly’s eye incorporates perhaps 28,000 small eyes, or ommatidia,” explained team-member Dr Jianliang Xiao from the University of Colorado at Boulder, US. “That’s the direction we want to move in,” he told BBC News.

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DNA Double Helix

Pretty much anything can be a computer, if it can compute logical functions, store data, and transmit information — even living cells. A team at Stanford University has accomplished one of the the final tasks necessary to turn cells into working computers: They’ve created a biological transistor, called a transcriptor, that uses DNA and RNA instead of electrons and responds to logical functions.

Drew Endy, an assistant professor of bioengineering, has previously made other vital contributions to biocomputing. Last year, his lab developed a “biological Internet” that can transmit genetic information between cells, as well as a rewritable data storage system for DNA.

Building a system with logic gates that can compute true-false answers from biochemical information is the third component in creating a biological computer.

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How fast do quantum interactions happen? Faster than light, 10,000 times faster.

That’s what a team of physicists led by Juan Yin at the University of Science and Technology of China in Shanghai found in an experiment involving entangled photons, or photons that remain intimately connected, even when separated by vast distances.They wanted to see what would happen if you tried assigning a speed to what Einstein called “spooky action at a distance.”

They didn’t find anything unexpected, but that wasn’t the point: in physics, sometimes it’s good to be sure. The group published their work on the ArXiv.org, a preprint server for physics papers.

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The electric fields that build up on honey bees as they fly, flutter their wings, or rub body parts together may allow the insects to talk to each other, a new study suggests. Tests show that the electric fields, which can be quite strong, deflect the bees’ antennae, which, in turn, provide signals to the brain through specialized organs at their bases.

Scientists have long known that flying insects gain an electrical charge when they buzz around. That charge, typically positive, accumulates as the wings zip through the air—much as electrical charge accumulates on a person shuffling across a carpet. And because an insect’s exoskeleton has a waxy surface that acts as an electrical insulator, that charge isn’t easily dissipated, even when the insect lands on objects, says Randolf Menzel, a neurobiologist at the Free University of Berlin in Germany.

Although researchers have suspected for decades that such electrical fields aid pollination by helping the tiny grains stick to insects visiting a flower, only more recently have they investigated how insects sense and respond to such fields. Just last month, for example, a team reported thatbumblebees may use electrical fields to identify flowers recently visited by other insects from those that may still hold lucrative stores of nectar and pollen. A flower that a bee had recently landed on might have an altered electrical field, the researchers speculated.

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New discovery may allow scientists to make fuel from CO2 in the atmosphere

Excess carbon dioxide in the Earth’s atmosphere created by the widespread burning of fossil fuels is the major driving force of global climate change, and researchers the world over are looking for new ways to generate power that leaves a smaller carbon footprint.

Now, researchers at the University of Georgia have found a way to transform the carbon dioxide trapped in the atmosphere into useful industrial products. Their discovery may soon lead to the creation of biofuels made directly from the carbon dioxide in the air that is responsible for trapping the sun’s rays and raising global temperatures. “Basically, what we have done is create a microorganism that does with carbon dioxide exactly what plants do—absorb it and generate something useful,” said Michael Adams, member of UGA’s Bioenergy Systems Research Institute, Georgia Power professor of biotechnology and Distinguished Research Professor of biochemistry and molecular biology in the Franklin College of Arts and Sciences.

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The Japanese have done it again! For the first time in human history,they have successfully utilized sperm cells created with stem-cell techniques to fertilize eggs and produce live, normal offspring. They  used embryonic stem cells of mice to make primordial germ cells,which are the precursors for sperm cells. Scientists have for ages  tried to create sperm by using stem cells in earlier in-vitro studies using mice and human cells, but up until now they haven’t been successful. The breakthrough research by the Asian scientists, led by Professor Mitinori Saitou from the Kyoto University, is published  as an abstract in the journal Cell, entitled: “Reconstitution of the Mouse Germ Cell Specification Pathway in Culture by Pluripotent Stem Cells”.

They then transplanted them into the testicles of infertile mice, after which the cells produced normal-looking sperm. The mature sperm cells were used to fertilize eggs and produced healthy, fertile offspring. These findings will encourage further research into the process of how primordial germ cells develop, something that has been difficult to investigate because these cells don’t grow in vitro. Whether future findings eventually will lead to new discoveries in human fertility remains a question. Human and mouse embryonic stem cells have different properties and any research of this kind with human stem cells will of course become an ethical issue as well.

Invisibility Cloak Research Moves Forward

Using a new kind of cloak that uses a very thin multilayer dielectric coating made of natural material, not metamaterial, researchers at Michigan Technological University demonstrated better cloaking efficiency than a similarly sized metamaterial cloak designed by using the transformation optics relations.

Michigan Technological University’s invisibility cloak researchers have done it again. They’ve moved the bar on one of the holy grails of physics: making objects invisible.

Just last month, Elena Semouchkina, an associate professor of electrical and computer engineering at Michigan Tech, and her graduate student, Xiaohui Wang, reported successful experimental demonstration of the use of non-conductive ceramic metamaterials to cloak cylindrical objects from microwave-length electromagnetic waves. Previously, Semouchkina had designed a non-conductive glass metamaterial cloak that worked with infrared frequency waves, which are shorter than microwaves.

Then, scarcely was the ink dry on their report in the IEEE Microwave and Wireless Components Letters, a journal published by the Institute of Electrical and Electronics Engineers, when they developed a different cloaking approach and published it in the American Institute of Physics journal, Applied Physics Letters.

This time, they used ordinary dielectric materials such as ceramics having differing dielectric permittivity—a measure of the response of a substance to an electrical field— instead of metamaterials, which are artificial materials with properties not found in nature. They found that they were able to cloak larger cylindrical objects and cloak them more effectively than they had using metamaterials.

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Scientists have tentatively identified several particles lurking deep inside the Earth’s mantle that could reveal how much heat the planet produces and confirm that the Earth formed from materials from the sun.

The wacky particles are called geoneutrinos, or the antimatter partners of neutrinos (exotic fundamental particles that can pass right through Earth), that form deep within the Earth’s mantle. Every matter particle has an antimatter partner particle that has an opposite charge, and when the two meet they annihilate each other. The findings were detailed described March 11 in the preprint journal arXiv.org.

Geoneutrinos aren’t the only particles scientists are hoping to find inside Earth.  An experiment using the Earth as a source of electrons recently narrowed down the search for a new force-bearing particle, possibly the so-called unparticle, placing tighter limits on the force it carries.

When Earth formed, the radioactive elements thorium and uranium were distributed in Earth’s interior at different concentrations within the crust (the planet’s outer layer) and mantle. As these elements within the mantle radioactively decay, they give off heat and also form subatomic particles known as geoneutrinos, said study co-author Aldo Ianni, a physicist at the Gran Sasso National Laboratory in Italy.

The heat formed from this decay is the engine that drives the motion of the viscous, oozing material that forms the Earth’s mantle. That, in turn can shift the tectonic plates, causing earthquakes. Whereas researchers have models to predict how much heat is generated inside the Earth, measuring it has proved tricky.

That’s partly because mantle lies miles beneath the Earth’s surface, so “if you want to understand how much heat is produced by these radioactive elements, the only way today to understand how much is this so-called radiogenic heat is through the geoneutrinos,” Ianni said.

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